SKIN
MICROBIOTA AND ITS INTERPLAY WITH WOUND AND BURN HEALING: IMPACT OF EPITHELIAL
BIOREGENERATOR
Major Gheorghe GIURGIU1, Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center,
Biomedicine, Bucharest, Romania
deniplant@gmail.com;
Telephone: +40 744 827 881
https://orcid.org/0000-0002-5449-2712
2Associate
Member of the Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest,
Romania
cojocaru.manole@gmail.com;
Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
ABSTRACT The skin microbiota is intimately coupled with
cutaneous health and disease. Interactions between commensal microbiota and the
multiple cell types involved in cutaneous wound healing regulate the immune
response and promote barrier restoration. This dialog between host cells and
the microbiome is dysregulated in chronic wounds and burns. To investigate
whether changes in composition were present in the skin microbiome of
individuals at risk of developing these lesions. Colonization of the wound and
burn with commensal bacteria may promote wound and burn healing by inducing
antimicrobial proteins such as Perforin-2, thus stimulating a protective immune
response against pathogenic bacteria. Wound and burn infection with
pathogenic bacteria results in Perforin-2 suppression in both hematopoietic and
nonhematopoietic cells and inhibition of healing. A new study now shows
that, in most cases, the causative agents of these infections are bacteria from
the patient's own skin. For this reason, authors
investigated the impact of Epithelial Bioregenerator to eliminate
microorganisms from the chronic wounds and burns.
Keywords: microbiome,
host-pathogen interactions, chronic wounds, burns, infection, Epithelial Bioregenerator
DOI
https://doi.org/10.56082/annalsarscibio.2024.1.109
